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So long as Google has web traffic, it will be able to monetize it. With some of the most popular apps around, from Gmail and Maps to the Play Store and Chrome, Alphabet has a major conduit that continues driving growth to its most reliable source of income — advertising.

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Market cap: $473 Billion 2018 YTD gain: 10.6%

Alibaba Group Holding Ltd (NYSE: ), often called the “Amazon of China,” could beat America’s Amazon to trillion-dollar status. At least, that’s according toMKM Partners.

“We think that BABA may have the best chance among internet mega-caps,” writes MKM in a note to clients. At a $473 billion market cap, it would have to grow 111% this year to meet the mark. That’s not impossible.

But like Amazon, Alibaba has a hand in everything … even in territory we typically associate with Google, search. Indeed, a few emerging markets are Discount Outlet Marni striped knitted Tshirt Shop For Online Sale The Cheapest Shipping Discount Sale Cheap Sale With Mastercard yDrowaP9T
, with India and Indonesia ceding 51% and 41% to Baba’s UC browser, respectively, versus 30% and 34% to Chrome.

What it will come down to, though, is Alibaba’s ability to beat earnings in a continued bull market. Increasing its ad load will go a long way toward accomplishing that.

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Market cap: $534 Billion 2018 YTD gain: 1.9%

Facebook Inc (NASDAQ: ) isn’t just another FANG stock, it’s one of the world’s most recognizable brands. And despite a rash of “fake news” complaints, a slowing ad load and the GOP tax plan’s alternative minimum tax muddying the waters, FB stock managed to gain an amazing 53%.

While you may recognize Facebook as the social network where your little cousin and grandmother both share the same memes, it’s quickly fitting into Microsoft Corporation’s (NASDAQ: ) role as an enterprise company.

Workplace by Facebook , for instance, is used by 30,000 organizations, up from 1,000 in 2016. And if you use Facebook at all on mobile, and chances are you do, then you’ve also likely seen its Marketplace and Video tabs.

Ad load may be slowing in the traditional sense of the News Feed, but the more verticals Facebook introduces to the network, the better its chances to monetize its users through various points.

There’s also Instagram, a thorn in Snap Inc’s (NYSE: ) side, Facebook Messenger and WhatsApp. Oh, and Oculus hasn’t even begun to show its potential yet.

Fig 4.

A. Schematic of full-length HIV used in C-E. B. Flow cytometric plots of CD133-sorted cord blood HSPCs cultured for 7 days and stained as in Fig 1D . Cells gated in left plot were overlaid on the total live population on the right. C. Representative flow cytometric plots of cord blood-derived CD133-sorted cells expanded for four days, infected with the indicated virus and harvested 2 days post-infection. Gag + cells are overlaid onto CD34 versus CD133 plots for the total live cell population and the percentage of Gag + cells in the CD133 high and CD133 low regions is indicated in the overlay. D. Summary graph of relative CD133 expression by mean fluorescence intensity (MFI) on HSPCs infected with the indicated HIV. Results were normalized to those for YU-2 infected cells for each experiment. E. Summary graph showing the frequency of Gag + cells falling into CD133 bright gate. Data was compiled from four cord blood experiments; mean ± standard deviation is indicated (**** p < 0.0001, 2-tailed paired t-test).

https://doi.org/10.1371/journal.ppat.1006509.g004

Fig 5. Targeting of intermediate progenitors by CCR5-tropic Envs is a conserved property extending to a transmitted/founder virus.

A. Schematic of HIV-7/SF-GFP construct and HIV envelope plasmid used to construct pseudotyped viruses used in C-E. B. Summary table of envelope proteins used to pseudotype HIV-7/SF-GFP virus. C. Representative flow plots of cord blood-derived CD133-sorted cells expanded for four days, transduced with the indicated virus and harvested 3 days post-infection for flow cytometric analysis. In each right panel, GFP + cells were overlaid onto plots of the total cell population and the percentage of GFP + cells in the CD133 high and CD133 low regions is indicated. Gates were determined based on isotype control antibody staining (top panel). D. Summary graph of CD133 MFI for experiments performed as in C. Results are compiled from 11 cord blood experiments. Mean ± standard deviation is indicated; n ≥3 for each envelope. 2-tailed Student’s t-test indicates significance for each HIV envelope with respect to VSV-G (** p < 0.01,*** p < 0.001, **** p < 0.0001). E. Data from (D) compiled by tropism. Mean ± standard deviation is indicated; one-way ANOVA, p = 0.0002, with Tukey’s Multiple Comparisons Test indicated (** p < 0.01 and *** p < 0.001).

https://doi.org/10.1371/journal.ppat.1006509.g005

The HIV receptor, CD4, is usually required for infection and is expressed on CD34 + HSPCs, although at low levels compared to CD4 + T cells [ 16 , 17 ]. If the relative level of CD4 expression on HSPCs determined susceptibility of HSPCs to infection, then CD4 expression would serve as an indicator of the subtypes of HSPCs potentially targeted by HIV. To examine this question, we treated HSPCs with a GFP-expressing lentiviral vector pseudotyped with CCR5- or CXCR4-tropic Env proteins ( Fig 6A and 6B ) and assessed CD4 levels on the GFP + transduced cells. We observed that HSPCs within a CD4 high flow cytometric gate displayed 2–30 times greater infection than CD4 low/- cells ( Fig 6A–6C ). The increased infection of CD4 high cells was not due to a greater capacity of these cells to support infection by this virus because the same virus pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G) demonstrated no such preference ( Fig 6B ). Further, CCR5-tropic envelopes had a significantly greater propensity to target CD4 high progenitors compared to CXCR4 and dual-tropic envelopes ( Fig 6B and 6C ). Thus, relative CD4 expression levels correlated with susceptibility of HSPCs to infection by HIV-1 and HSPCs that express higher levels of CD4 are more likely to become infected.

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by Matt Egan @MattEganCNN July 13, 2018: 4:15 PM ET
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Buffett acknowledges Wells Fargo's 'cardinal sin'

On Friday, Wells Fargo ( ) disclosed it's setting aside another $285 million to refund foreign-exchange and wealth-management clients

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That's on top of Wells Fargo's infamous consumer scandals. The bank has already paid out rebates to customers for opening fake accounts in their names, forcing them into car insurance they didn't need and charging them mortgage fees they didn't deserve.

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. The company said on Friday its profits dropped more than feared as expenses mounted. Wells Fargo's deposits also dipped because of tough penalties from the Federal Reserve that limit the size of the bank's balance sheet.

Wells Fargo said that a third-party investigation into its foreign-exchange business found the bank may be on the hook for $171 million to clients.

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